Skip to main content

Different Types of Hand Disinfectants Used in Pharmaceuticals

Different Types of Hand Disinfectants Used in Pharmaceuticals

Hand disinfectants are used to sanitize hand before working in pharmaceuticals therefore these must be effective to produce the best quality products.

There are different types of hand disinfectants used in pharmaceuticals. These differences can be attributed to the fact that each one varies in its mode of action and the level of activity. It is important to utilize different types of sanitizers in pharmaceuticals because the mode of action in each is needed to prevent the resistance of microbes.

Hand sanitizers are antiseptics used in conjunction with soap and water as part of an infection control program. The most common forms of disinfectants include gels, liquids, foams, mists and wipes.

Hand Disinfectants and their Effectiveness

There are currently three classifications of hand disinfectants available: these include alcohols, quaternary ammonium compounds and triclosan. Some disinfectant products contain ethanol. Ethanol is particularly effective against gram positive, gram negative and fungal organisms. While ethanol does work to weaken proteins in infectious organisms, it does not kill bacterial spores and some types of enveloped viruses. Ethanol can also be flammable.

Benzalkonium chloride and benzethonium chloride are quaternary ammonium compounds. Because of their non-flammable properties, quaternary ammonium compounds are safe for use around hyfrecator or electrocautery devices. They are also fungistatic, bacteriostatic against gram-positive bacteria, bacteriostatic against some types of gram-negative bacteria and are not active against enveloped viruses.

One thing to note about quaternary ammonium compounds is that they are not entirely effective against Staphylococcus aureus. This is due to the fact that quaternary ammonium compounds absorb to the cytoplasmic membrane of microbes which can result in the leakage of cytoplasmic contents.

Triclosan is present in different types of hand sanitizers used in pharmaceuticals. Common in most store-bought sanitizers, triclosan damages the  cell membranes of organisms but does not do well to ward off bacteria like Pseudomonas.

The use of hand disinfectants is recommended in order to decrease the spread of infectious diseases and the killing of micro-organisms on the skin, but should not be a substitute for regular hand washing.

Are Hand Disinfectants More Effective Than Washing Hands?

Whether or not different types of hand disinfectants used in pharmaceuticals are more effective than hand washing still remains a question today. Alcohol-based sanitizers that contain more than 60 percent of alcohol are said to be most effective. This may be true, but the product may not stay long enough on the skin to provide the kind of protection needed. If the alcohol is not present long enough to fight off bacteria, sanitizers may not be as effective as washing the hands.

Studies suggest that ethanol is better at killing microbes than isopropanol, however, it does offer proper protection against bacteria, fungi and  viruses. Triclosan and benzalkonium chloride are ideal at high concentrations but have also been found to contribute to antibiotic-resistant microbes. When used inappropriately or more than needed, the potential for antibiotic resistance increases.

It is recommended by the Centers for Disease Control and Prevention (CDC) that hand disinfectants be used in high-risk settings, when hands are visibly dirty and before and after using the restroom. It is also best to avoid products with high irritancy potential for continued use.

Labels:

Comments

Post a Comment

If you have any doubts, please let me know

Popular posts from this blog

Checklist for Audit in Sterile Area

Checklist for Audit in Sterile Area Checklist to verify the sterile manufacturing area before the audit. 1. Is there any SOP giving details for activity/ movement in the sterile area. 2. Verify the suitability of system for sanitization of hands. 3. Is there the SOP on entry-exit; gowning and de-gowning into the critical area available? 4. Verify the availability of following records:  Air pressure differential  Particulate monitoring  Temperature  Humidity  Microbiological monitoring by settle plate 5. Are these records available and maintained as per SOPs? 6. Check the above mentioned individual records. Are the entries within specifications mentioned in SOP/ MTPs. 7. Is the controlled copy of MTP pertaining to monitoring by settle plate available to plant person? 8. Are the location for settle plates identified and the chart/ layout available with plant? 9. Are the following areas monitored for parameters mentioned in step 4:  Air-lock to the critical ar...
Post a Comment
Read more

Aseptic Filling Process (Media Fill) Validation Protocol in Sterile Pharmaceuticals

Aseptic Filling Process (Media Fill) Validation Protocol in Sterile Pharmaceuticals Validation of sterile manufacturing process by media fill validation test as per PICS guidelines for aseptic validation or aseptic process simulation. 1.0 OBJECTIVE 1.1 To define procedures for validating and maintaining the validation of all aseptic filling processes and qualification of the quality of the product by system/facility/equipment. 2.0 SCOPE 2.1 This procedure applies to all aseptically filled sterile products intended for human use. 3.0 RESPONSIBILITY 3.1 The Validation personnel coordinate the aseptic filling validation program and write the sterile media aseptic filling processes reports. 3.2 Manufacturing personnel the sterile media aseptic filling processes and performs the sterile media fills. 3.3 QA personnel perform the sampling and assist with the IPQA monitoring required for each sterile media fill. 3.4 QC personnel to perform the testing and assist with the monitoring required fo...
Post a Comment
Read more

Blow Fill Seal (BFS) and Form Fill Seal (FFS) Technology in Sterile Manufacturing

Blow Fill Seal (BFS) and Form Fill Seal (FFS) Technology in Sterile Manufacturing Know about sterile pharmaceutical production using Blow Fill Seal (BFS) and Form Fill Seal (FFS) technology. Both of these techniques are used to manufacture  sterile pharmaceutical products   as parenteral (LVP & SVP), infusions, ophthalmic and inhalation products. These are automated techniques to prepare sterile products. The basic concept of the  FFS   and BFS is to reduce the  contamination   by forming the container, filling and sealing in a closed sterile chamber of the machine. There is no personnel intervention to reduce the chances of the contamination during the manufacturing of sterile products. It gives more production at very low operational cost with the high assurance of  sterility . Blow fill seal technology is widely used and accepted by the various pharmaceutical regulatory authorities as US-FDA and MHRA. The system is being used for over 30 years a...
Post a Comment
Read more